Nucleotides for mRNA Modification
Synthetic messenger RNA (mRNA) can be used to deliver exogenous genetic information inside cells that is converted by the cellular translational machinery into the encoded protein which subsequently induces a cellular response depending on its biological function.
Therapeutic protein encoding mRNAs have most recently gained increasing attention as versatile protein delivery molecules in non-viral gene therapy mostly due to their superior safety profile compared to plasmid DNA-based approaches (inability to integrate into the host genome). Enzymatic incorporation of a set several nucleotide analogs (single or combined) during the transcription process markedly improves the pharmacokinetic properties of in vitro transcribed mRNA both in terms of stability (increased nuclease resistance) and decreased immunogenicity.
Our Nucleotide Features Execellent Quality:
– HPLC purity >99%，
– Transcription effect guaranteed
– No protease, DNase or RNase contamination
– No residual heavy metal ions
– Endotoxin levels < 1 EU/ml